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Pharmacogenomics. 2018 Apr;19(6):539-546. doi: 10.2217/pgs-2018-0197. Epub 2018 Apr 9.

A genetic polymorphism in the CYP1B1 gene in patients with squamous cell carcinoma of the esophagus: an Iranian Mashhad cohort study recruited over 10 years.

Author information

1
Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
2
Department of Biology, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
3
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
5
Recombinant Proteins Research Group, The Research Institute of Biotechnology, Ferdowsi University of Mashhad, Iran.
6
Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
7
Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
8
Division of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, Sussex BN1 9PH, UK.

Abstract

AIM:

Esophageal cancer is the eighth most common cancer globally and the seventh most common cause of cancer-related deaths in men. Recent studies have shown that CYP450, family 1, subfamily B, polypeptide 1, which plays a role in the metabolism of xenobiotics, is associated with several cancers. Therefore, in the present study we investigated the association between a genetic variant, CYP1B1-rs1056836 gene, with the clinical characteristics of patients with squamous cell carcinoma of the esophagus (ESCC).

METHOD:

In this study, 117 patients with ESCC and 208 healthy controls were recruited. DNA was extracted and genotyped using real-time PCR-based TaqMan. Kaplan-Meier curves were utilized to assess overall and progression-free survival. To evaluate the relationship between clinicopathological data, genotypic frequencies, disease prognosis and survival, Pearson's χ2 and t-test were used. Logistic regression was utilized to assess the association between the risk of ESCC and genotypes.

RESULTS:

The genotypic frequency for GG, GC and CC were 58.6, 29.8 and 11.5%, respectively, in the healthy subjects and 51.8, 36.14 and 12% in the ESCC group. An association between the GG genotype and stage of ESCC was found. Also, statistically significant results were not found for this variation and risk of ESCC.

CONCLUSION:

Our findings suggest a relationship between the CYP1B1-rs1056836 genetic polymorphism and clinical features of ESCC, supporting further studies in larger populations in different ethnic groups, taking into account potentially important environmental factors such as diet.

KEYWORDS:

cytochrome p450; esophagus squamous cell carcinoma

PMID:
29629838
DOI:
10.2217/pgs-2018-0197
[Indexed for MEDLINE]

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