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J Infect Chemother. 2018 Jul;24(7):524-530. doi: 10.1016/j.jiac.2018.02.008. Epub 2018 Apr 5.

Interferon-free treatment choice according to baseline RASs leads to high SVR rates in HCV genotype 1 infected patients.

Author information

1
University Hospital Frankfurt, Department of Gastroenterology and Hepatology, 60590 Frankfurt, Germany. Electronic address: kai-henrik.peiffer@kgu.de.
2
University Hospital Frankfurt, Department of Gastroenterology and Hepatology, 60590 Frankfurt, Germany.
3
University Hospital Frankfurt, Department of Gastroenterology and Hepatology, 60590 Frankfurt, Germany; St. Josefs Hospital, Department of Gastroenterology, 65189 Wiesbaden, Germany.

Abstract

AIM:

Different combinations of direct antiviral agents (DAA) lead to high SVR rates in HCV genotype 1 infected patients. However, presence of baseline resistance-associated substitutions (RASs) represents a major risk factor for treatment failure. It is unknown whether choice of treatment based on RASs has the potential to decrease virologic failure rates.

METHODS:

Population-based sequencing of NS3 and NS5A genes was performed in HCV genotype 1 infected patients at a German university hospital. Treatment was individually selected based on resistance analyses.

RESULTS:

In total, 319 patients (50% treatment-experienced and 30% with cirrhosis) were included. With the treatment choice based on the baseline NS3 and NS5A resistance profile SVR rates between 96 and 100% were observed in all subgroups, including treatment-experienced patients with cirrhosis and HCV genotype 1a infected cirrhotic patients.

CONCLUSIONS:

The choice of treatment based on the RASs status at baseline may be beneficial for optimizing treatment efficacy in patients with HCV genotype 1 infection and risk factors for treatment failure.

KEYWORDS:

Hepatitis C virus; RAS; RAV

PMID:
29628383
DOI:
10.1016/j.jiac.2018.02.008
[Indexed for MEDLINE]

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