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Explore (NY). 2018 May - Jun;14(3):224-229. doi: 10.1016/j.explore.2017.12.007. Epub 2018 Mar 7.

Efficacy and Safety of Xiaoyao Formula as an Adjuvant Treatment for Post-Stroke Depression: A Meta-Analysis.

Author information

1
Institute of Molecular Biology & Translational Medicine, the Affiliated People's Hospital, Jiangsu University, No. 8 Dianli Road, Zhenjiang, Jiangsu 212002, PR China.
2
Department of Nuclear Medicine, Affiliated Hospital of Jiangsu University, No. 438 Jiefang Road, Zhenjiang, Jiangsu 212001, PR China. Electronic address: chenyuehuazj@163.com.
3
Institute of Molecular Biology & Translational Medicine, the Affiliated People's Hospital, Jiangsu University, No. 8 Dianli Road, Zhenjiang, Jiangsu 212002, PR China. Electronic address: jszjfanyu@163.com.

Abstract

OBJECTIVE:

To systematically evaluate the efficacy and safety of Xiaoyao formula (XYF) as an adjuvant treatment of post-stroke depression (PSD) by conducting a meta-analysis.

METHODS:

Pubmed, Embase, Cochrane Library, CNKI, VIP, and Wanfang databases were searched up to May 2016. Randomized controlled trials investigating XYF plus antidepressants versus antidepressants alone for patients with PSD were considered.

RESULTS:

A total of 607 PSD patients were identified from 7 trials. Adjuvant treatment with XYF had additional benefits in terms of improved total response rates (risk ratio [RR] 1.21; 95% confidence interval [CI]: 1.12-1.30), reduced Hamilton's depressive scale (weighted mean difference [WMD] -5.21; 95% CI: -7.48 to -2.95), and decreased Scandinavian Stroke Scale (WMD -6.35; 95% CI: -8.27 to -4.43). No serious adverse events were observed in any of the included trials.

CONCLUSIONS:

Adjuvant treatment with XYF appears to have additional benefits in the treatment of PSD, without increasing serious adverse events.

KEYWORDS:

Xiaoyao formula; Xiaoyao pill; meta-analysis; post-stroke depression

PMID:
29628336
DOI:
10.1016/j.explore.2017.12.007
[Indexed for MEDLINE]

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