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Int J Cardiol. 2018 Aug 1;264:172-178. doi: 10.1016/j.ijcard.2018.03.128. Epub 2018 Mar 29.

LDL particle size and composition and incident cardiovascular disease in a South-European population: The Hortega-Liposcale Follow-up Study.

Author information

1
Cardiometabolic and Renal Risk, Biomedical Research Institute INCLIVA, Valencia, Spain; Department of Internal Medicine, Hospital Clinic of Valencia, University of Valencia, Spain.
2
Biosfer Teslab, Reus, Spain; Metabolomics platform, Rovira i Virgili University, Tarragona, Spain; Intitut d'Investigació Sanitària Pere i Virgili (IISPV), Reus, Spain.
3
Cardiometabolic and Renal Risk, Biomedical Research Institute INCLIVA, Valencia, Spain; Departments of Environmental Health Sciences, Medicine, and Epidemiology, Johns Hopkins Medical Institutions, Baltimore, USA.
4
Biosfer Teslab, Reus, Spain.
5
Cardiometabolic and Renal Risk, Biomedical Research Institute INCLIVA, Valencia, Spain.
6
Metabolomic and Molecular Image Lab, Biomedical Research Institute INCLIVA, Valencia, Spain.
7
Department of Internal Medicine, University Hospital Rio Hortega, Valladolid, Spain.
8
Department of Internal Medicine, Hospital Clinic of Valencia, University of Valencia, Spain; CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Institute of Health Carlos III, Madrid, Spain.
9
CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Institute of Health Carlos III, Madrid, Spain.
10
Cardiometabolic and Renal Risk, Biomedical Research Institute INCLIVA, Valencia, Spain; Department of Internal Medicine, Hospital Clinic of Valencia, University of Valencia, Spain; CIBER 03/06 Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, Madrid, Spain. Electronic address: josep.redon@uv.es.

Abstract

BACKGROUND:

The association of low-density lipoprotein (LDL) particle composition with cardiovascular risk has not been explored before. The aim was to evaluate the relationship between baseline LDL particle size and composition (proportions of large, medium and small LDL particles over their sum expressed as small-LDL %, medium-LDL % and large-LDL %) and incident cardiovascular disease in a population-based study.

METHODS:

Direct measurement of LDL particles was performed using a two-dimensional NMR-technique (Liposcale®). LDL cholesterol was assessed using both standard photometrical methods and the Liposcale® technique in a representative sample of 1162 adult men and women from Spain.

RESULTS:

The geometric mean of total LDL particle concentration in the study sample was 827.2 mg/dL (95% CI 814.7, 839.8). During a mean follow-up of 12.4 ± 3.3 years, a total of 159 events occurred. Medium LDL particles were positively associated with all cardiovascular disease, coronary heart disease (CHD) and stroke after adjustment for traditional risk factors and treatment. Regarding LDL particle composition, the multivariable adjusted hazard ratios for CHD for a 5% increase in medium and small LDL % by a corresponding decrease of large LDL % were 1.93 (1.55, 2.39) and 1.41 (1.14, 1.74), respectively.

CONCLUSIONS:

Medium LDL particles were associated with incident cardiovascular disease. LDL particles showed the strongest association with cardiovascular events when the particle composition, rather than the total concentration, was investigated. A change in baseline composition of LDL particles from large to medium and small LDL particles was associated with an increased cardiovascular risk, especially for CHD.

KEYWORDS:

Cardiovascular disease; LDL particles; NMR metabolomics; Prospective study

PMID:
29628276
DOI:
10.1016/j.ijcard.2018.03.128
[Indexed for MEDLINE]

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