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Neuron. 2018 Apr 18;98(2):366-379.e4. doi: 10.1016/j.neuron.2018.03.024. Epub 2018 Apr 5.

Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.

Author information

1
Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA.
2
Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA. Electronic address: adam.carter@nyu.edu.

Abstract

Reciprocal interactions between the prefrontal cortex (PFC) and thalamus play a critical role in cognition, but the underlying circuits remain poorly understood. Here we use optogenetics to dissect the specificity and dynamics of cortico-thalamo-cortical networks in the mouse brain. We find that cortico-thalamic (CT) neurons in prelimbic PFC project to both mediodorsal (MD) and ventromedial (VM) thalamus, where layer 5 and 6 inputs activate thalamo-cortical (TC) neurons with distinct temporal profiles. We show that TC neurons in MD and VM in turn make distinct connections in PFC, with MD preferentially and strongly activating layer 2/3 cortico-cortical (CC) neurons. Finally, we assess local connections from superficial CC to deep CT neurons, which link thalamo-cortical and cortico-thalamic networks within the PFC. Together our findings indicate that PFC strongly drives neurons in the thalamus, whereas MD and VM indirectly influence reciprocally connected neurons in the PFC, providing a mechanistic understanding of these circuits.

PMID:
29628187
PMCID:
PMC6422177
DOI:
10.1016/j.neuron.2018.03.024
[Indexed for MEDLINE]
Free PMC Article

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