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Virology. 2018 Jun;519:12-16. doi: 10.1016/j.virol.2018.03.025. Epub 2018 Apr 5.

Novel orthohepeviruses in wild rodents from São Paulo State, Brazil.

Author information

1
Virology Research Center, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, Monte Alegre, 14049-900 Ribeirão Preto, SP, Brazil; MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom. Electronic address: wmarciel@usp.br.
2
Virology Research Center, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, Monte Alegre, 14049-900 Ribeirão Preto, SP, Brazil.
3
Virology Research Center, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, Monte Alegre, 14049-900 Ribeirão Preto, SP, Brazil; Laboratory Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
4
MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
5
Center for Technological Innovations, Evandro Chagas Institute, Ministry of Health, Ananindeua, Pará, Brazil.

Abstract

The Hepeviridae comprise single-stranded positive-sense RNA viruses classified into two genera, Orthohepevirus and Piscihepevirus. Orthohepeviruses have a wide host range that includes rodents, but previous studies had been restricted to rodents of the Muridae family. In this study, we applied a high-throughput sequencing approach to examine the presence of orthohepeviruses in rodents from São Paulo State, Brazil. We also used RT-PCR to determine the frequency of orthohepeviruses in our sampled population. We identified novel orthohepeviruses in blood samples derived from Necromys lasiurus (1.19%) and Calomys tener (3.66%). Therefore, our results expand the host range and viral diversity of the Hepeviridae family.

KEYWORDS:

Hepatitis E virus; Hepeviridae; Orthohepevirus; Rodent-borne viruses; Viral hepatitis

PMID:
29627586
PMCID:
PMC5998382
DOI:
10.1016/j.virol.2018.03.025
[Indexed for MEDLINE]
Free PMC Article

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