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Int J Biochem Cell Biol. 2018 Jun;99:109-113. doi: 10.1016/j.biocel.2018.04.002. Epub 2018 Apr 5.

Perivascular cell αv integrins as a target to treat skeletal muscle fibrosis.

Author information

1
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
2
Anatomy of Domestic and Wild Animals Program, Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil.
3
Department of Radiology, Columbia University Medical Center, New York, NY, USA.
4
Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
5
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Anatomy of Domestic and Wild Animals Program, Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil; Department of Radiology, Columbia University Medical Center, New York, NY, USA. Electronic address: birbrair@icb.ufmg.br.

Abstract

Fibrosis following injury leads to aberrant regeneration and incomplete functional recovery of skeletal muscle, but the lack of detailed knowledge about the cellular and molecular mechanisms involved hampers the design of effective treatments. Using state-of-the-art technologies, Murray et al. (2017) found that perivascular PDGFRβ-expressing cells generate fibrotic cells in the skeletal muscle. Strikingly, genetic deletion of αv integrins from perivascular PDGFRβ-expressing cells significantly inhibited skeletal muscle fibrosis without affecting muscle vascularization or regeneration. In addition, the authors showed that a small molecule inhibitor of αv integrins, CWHM 12, attenuates skeletal muscle fibrosis. From a drug-development perspective, this study identifies a new cellular and molecular target to treat skeletal muscle fibrosis.

KEYWORDS:

Fibrosis; Integrins; PDGFRβ; Perivascular cells; Skeletal muscle

PMID:
29627438
PMCID:
PMC6159891
[Available on 2019-06-01]
DOI:
10.1016/j.biocel.2018.04.002

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