Format

Send to

Choose Destination
Trends Endocrinol Metab. 2018 Sep;29(9):602-605. doi: 10.1016/j.tem.2018.03.012. Epub 2018 Apr 5.

Altered Cellular Metabolism Drives Trained Immunity.

Author information

1
Molecular and Translational Cardiology, Department of Cardiology, University Hospital Münster, Münster, Germany. Electronic address: Yahya.Sohrabi@ukmuenster.de.
2
Molecular and Translational Cardiology, Department of Cardiology, University Hospital Münster, Münster, Germany; Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands.
3
Molecular and Translational Cardiology, Department of Cardiology, University Hospital Münster, Münster, Germany. Electronic address: Hannes.Findeisen@ukmuenster.de.

Abstract

Exposing innate immune cells to an initial insult induces a long-term proinflammatory response due to metabolic and epigenetic alterations which encompass an emerging new concept called trained immunity. Recent studies provide novel insights into mechanisms centered on metabolic reprogramming which induce innate immune memory in hematopoietic stem cells and monocytes.

KEYWORDS:

HSPCs; epigenetics; immunometabolism; monocytes/macrophages; trained immunity

PMID:
29627292
DOI:
10.1016/j.tem.2018.03.012

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center