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Public Health. 2018 Jun;159:78-88. doi: 10.1016/j.puhe.2018.01.036. Epub 2018 Apr 5.

Association between maternal depression and risk of infant diarrhea: a systematic review and meta-analysis.

Author information

1
CMH Lahore Medical College and Institute of Dentistry, Lahore Cantt 54600, Pakistan.
2
Department of Pediatrics, Faculty of Medicine (for Girls), Al-Azhar University, Cairo 11651, Egypt.
3
Buleleng Regency General Hospital, Singaraja City, Bali 81113, Indonesia.
4
Faculty of Medicine, University of Constantine 3, Constantine 25000, Algeria.
5
Laboratory of Stem Cell Research and Application, University of Science, VNU, Ho Chi Minh City 700000, Viet Nam.
6
University of Medicine and Pharmacy, Ho Chi Minh City 81112, Viet Nam.
7
Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
8
Faculty of Medicine, Minia University, Minia 61519, Egypt.
9
Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt.
10
Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
11
Evidence Based Medicine Research Group & Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. Electronic address: nguyentienhuy@tdt.edu.vn.

Abstract

OBJECTIVE:

To systematically review the evidence for an association between maternal depression and the risk of diarrheal illness in infants.

STUDY DESIGN:

This study is a meta-analysis.

METHODS:

Nine databases were searched systematically for studies that investigated the risk of diarrheal illness in infants born to mothers with depression.

RESULTS:

Our search strategy yielded 10 studies of the association between maternal depression and the risk of diarrheal illness in infants: eight studies of postnatal depression, two studies of antenatal depression, and one study of perinatal depression. Our meta-analysis showed that infants born to mothers with postnatal depression were more likely to develop diarrheal illness (odds ratio [OR] = 1.902, 95% confidence interval [95% CI] = 1.385-2.612, P < 0.001, n = 18,585). A similar trend was noted for antenatal depression (OR = 2.703, 95% CI = 0.920-7.942, P = 0.071, n = 583). Only one study reported an association between perinatal depression and risk of diarrhea in infants (OR = 1.848, log OR = 0.614, standard error = 0.093, n = 107,587).

CONCLUSIONS:

Only a few studies so far have identified an association between maternal depression and risk of diarrhea in infants. The evidence available to date suggests that infants born to mothers with depression are more likely to develop diarrhea than infants whose mothers do not have depression.

KEYWORDS:

Depression; Diarrhea; Infant; Meta-analysis; Systematic review

PMID:
29627116
DOI:
10.1016/j.puhe.2018.01.036
[Indexed for MEDLINE]

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