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Neoplasia. 2018 May;20(5):510-523. doi: 10.1016/j.neo.2018.03.005. Epub 2018 Apr 5.

Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings.

Author information

1
Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA center, University of Ferrara, Ferrara, Italy; Cecilia Hospital, GVM Care & Research, E.S.: Health Science Foundation, Cotignola, Italy.
2
Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA center, University of Ferrara, Ferrara, Italy.
3
KU Leuven, Lab. Molecular and Cellular Signaling, Dept. Cellular and Molecular Medicine and Leuven Kanker Instituut, Campus Gasthuisberg O&N 1 Box 802, Herestraat 49, 3000 Leuven, Belgium.
4
Department of Pathology, The Children's Memorial Health Institute, Warsaw, Poland.
5
Department of Biochemistry, Nencki Institute of Experimental Biology, Warsaw, Poland.
6
Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA center, University of Ferrara, Ferrara, Italy. Electronic address: grgclt@unife.it.
7
Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA center, University of Ferrara, Ferrara, Italy; Cecilia Hospital, GVM Care & Research, E.S.: Health Science Foundation, Cotignola, Italy; CNR Institute of Cell Biology and Neurobiology, Monterotondo, Italy. Electronic address: paolo.pinton@unife.it.

Abstract

Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) are highly specialized subcellular compartments that are shaped by ER subdomains juxtaposed to mitochondria but are biochemically distinct from pure ER and pure mitochondria. MAMs are enriched in enzymes involved in lipid synthesis and transport, channels for calcium transfer, and proteins with oncogenic/oncosuppressive functions that modulate cell signaling pathways involved in physiological and pathophysiological processes. The term "cancer" denotes a group of disorders that result from uncontrolled cell growth driven by a mixture of genetic and environmental components. Alterations in MAMs are thought to account for the onset as well as the progression and metastasis of cancer and have been a focus of investigation in recent years. In this review, we present the current state of the art regarding MAM-resident proteins and their relevance, alterations, and deregulating functions in different types of cancer from a cell biology and clinical perspective.

PMID:
29626751
PMCID:
PMC5916088
DOI:
10.1016/j.neo.2018.03.005
[Indexed for MEDLINE]
Free PMC Article

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