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Urology. 2018 Sep;119:5-16. doi: 10.1016/j.urology.2018.03.028. Epub 2018 Apr 4.

What Is the Role of α-Blockers for Medical Expulsive Therapy? Results From a Meta-analysis of 60 Randomized Trials and Over 9500 Patients.

Author information

1
Glasgow Urological Research Unit, Department of Urology, Queen Elizabeth University Hospital, Glasgow, United Kingdom; School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, United Kingdom; College of Medicine, Islamic Universities of Gaza, Gaza, Palestine; Young Academic Urologists Urolithiasis and Endourology Group of the European Association of Urology, Southampton, United Kingdom.
2
Young Academic Urologists Urolithiasis and Endourology Group of the European Association of Urology, Southampton, United Kingdom. Electronic address: patrick.jones1@nhs.net.
3
Glasgow Urological Research Unit, Department of Urology, Queen Elizabeth University Hospital, Glasgow, United Kingdom.
4
Young Academic Urologists Urolithiasis and Endourology Group of the European Association of Urology, Southampton, United Kingdom.
5
Urology Department, Hamad Medical Corporation, Doha, Qatar.
6
Urology Department, Urology and Nephrology Centre, Mansoura University, Mansoura, Egypt.

Abstract

Use of α-blockers for medical expulsive therapy (MET) has been the subject of huge debate in urology. Moreover, there have been a number of randomized controlled trials with differing results. We conducted a systematic review and meta-analysis of randomized controlled trials investigating the efficacy of α-blockers for MET. This review confirms there is a role for α-blockers in MET for ureteric stones specifically in stones >5 mm and distal ureteric stones, which is associated with improved stone expulsion. However, there is a slight increase in risk of nonsignificant side effects.

PMID:
29626570
DOI:
10.1016/j.urology.2018.03.028
[Indexed for MEDLINE]

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