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Adv Drug Deliv Rev. 2018 Mar 15;128:29-53. doi: 10.1016/j.addr.2018.04.001. Epub 2018 Apr 5.

Microfluidics in nanoparticle drug delivery; From synthesis to pre-clinical screening.

Author information

1
School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, Korea; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta 30332, GA, USA.
2
School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, Korea.
3
Bioengineering, Seoul National University, Seoul 151-744, Korea.
4
George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta 30332, GA, USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta 30332, GA, USA; Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta 30332, GA, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta 30332, GA, USA.
5
School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, Korea. Electronic address: njeon@snu.ac.kr.

Abstract

Microfluidic technologies employ nano and microscale fabrication techniques to develop highly controllable and reproducible fluidic microenvironments. Utilizing microfluidics, lead compounds can be produced with the controlled physicochemical properties, characterized in a high-throughput fashion, and evaluated in in vitro biomimetic models of human organs; organ-on-a-chip. As a step forward from conventional in vitro culture methods, microfluidics shows promise in effective preclinical testing of nanoparticle-based drug delivery. This review presents a curated selection of state-of-the-art microfluidic platforms focusing on the fabrication, characterization, and assessment of nanoparticles for drug delivery applications. We also discuss the current challenges and future prospects of nanoparticle drug delivery development using microfluidics.

KEYWORDS:

3D culture; Drug delivery; Microfluidics; Nanomedicine; Nanotechnology; Organ-on-a-chip

PMID:
29626551
DOI:
10.1016/j.addr.2018.04.001

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