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EMBO Mol Med. 2018 May;10(5). pii: e8763. doi: 10.15252/emmm.201708763.

Amyloid blood biomarker detects Alzheimer's disease.

Author information

1
Department of Biophysics, Ruhr-University Bochum, Bochum, Germany.
2
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
3
Department of Clinical Sciences, Lund University, Lund, Sweden.
4
Saarland Cancer Registry, Saarbrücken, Germany.
5
Department of Psychiatry, Psychotherapy and Psychosomatics, University of Halle, Halle, Germany.
6
Memory Clinic, Skåne University Hospital, Malmö, Sweden.
7
Department of Biophysics, Ruhr-University Bochum, Bochum, Germany gerwert@bph.rub.de.
8
Network Aging Research (NAR), University of Heidelberg, Heidelberg, Germany.

Abstract

Alzheimer's disease (AD) is currently incurable, but there is general agreement that a minimally invasive blood biomarker for screening in preclinical stages would be crucial for future therapy. Diagnostic tools for detection of AD are either invasive like cerebrospinal fluid (CSF) biomarkers or expensive such as positron emission tomography (PET) scanning. Here, we determine the secondary structure change of amyloid-β (Aβ) in human blood. This change used as blood amyloid biomarker indicates prodromal AD and correlates with CSF AD biomarkers and amyloid PET imaging in the cross-sectional BioFINDER cohort. In a further population-based longitudinal cohort (ESTHER), the blood biomarker detected AD several years before clinical diagnosis in baseline samples with a positive likelihood ratio of 7.9; that is, those who were diagnosed with AD over the years were 7.9 times more likely to test positive. This assay may open avenues for blood screening of early AD stages as a funnel for further more invasive and expensive tests.

KEYWORDS:

ESTHER ; Alzheimer's disease diagnosis; BioFINDER; amyloid‐β in blood plasma; immuno‐infrared‐sensor

PMID:
29626112
PMCID:
PMC5938617
DOI:
10.15252/emmm.201708763
[Indexed for MEDLINE]
Free PMC Article

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