Role of genetic variations on MHC class I antigen-processing genes in human cancer and viral-mediated diseases

Mol Immunol. 2019 Sep:113:11-15. doi: 10.1016/j.molimm.2018.03.024. Epub 2018 Apr 4.

Abstract

Cytotoxic T lymphocytes constantly monitor peptide-MHC class I complexes on the cell surface to eliminate transformed and virally infected cells expressing peptides derived from abnormal proteins. The generation of antigenic peptides and their loading on MHC class I molecules is a multistep process involving different molecules that constitute the so-called antigen processing and presentation machinery (APM). To avoid immune-mediated elimination, human tumors and pathogens have adopted different strategies including loss of MHC class I expression and dysregulation of APM genes and proteins. Here, we summarize recent knowledge on genetic variations in APM genes and their association with cancer development and viral-mediated diseases.

Keywords: MHC class I antigen processing; Single nucleotide polymorphism; Tumor; Viral infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigen Presentation / immunology*
  • Genes, MHC Class I / immunology*
  • Genetic Variation / immunology*
  • Histocompatibility Antigens Class I / immunology
  • Humans
  • Neoplasms / immunology*
  • Peptides / immunology*
  • T-Lymphocytes, Cytotoxic / immunology*
  • Virus Diseases / immunology*

Substances

  • Histocompatibility Antigens Class I
  • Peptides