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Environ Toxicol Pharmacol. 2018 Apr;59:172-181. doi: 10.1016/j.etap.2018.03.010. Epub 2018 Mar 17.

Urinary phthalate metabolite concentrations in girls with premature thelarche.

Author information

1
Akdeniz University, Faculty of Medicine, Department of Pediatric Endocrinology, Antalya, Turkey. Electronic address: erdem@drerdemdurmaz.com.
2
Hacettepe University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey. Electronic address: erkekp@hacettepe.edu.tr.
3
Hacettepe University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey; Atatürk University, Faculty of Pharmacy, Department of Toxicology, Erzurum, Turkey. Electronic address: aliasci@atauni.edu.tr.
4
Akdeniz University, Faculty of Medicine, Department of Pediatric Endocrinology, Antalya, Turkey. Electronic address: sakcuri@nakdeniz.edu.tr.
5
Akdeniz University, Faculty of Medicine, Department of Pediatric Endocrinology, Antalya, Turkey. Electronic address: ibircan@akdeniz.edu.tr.
6
Hacettepe University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey. Electronic address: bgiray@Hacettepe.edu.tr.

Abstract

In girls, breast development before eight years of age is called "premature thelarche (PT)". There are few studies in literature that show the interaction between PT and phthalate exposure. The aim of this study was to determine the urinary levels of di-(2-ethylhexyl) phthalate (DEHP) metabolites and other phthalate metabolites in girls with PT. PT group consisted of 29 newly diagnosed subjects. Control group comprised of healthy age-matched girls (n = 25). Urinary phthalate metabolite concentrations were measured by liquid chromatography/tandem mass spectroscopy (LC-MS/MS). The urinary concentrations of mono-(2-ethyl-hexyl)phthalate (MEHP) in the PT group (33.96 ± 6.88 μg/g creatinine) were found to be significantly higher compared to control group (11.54 ± 1.39 μg/g creatinine, p = 0.002). In PT group, %MEHP was also markedly higher vs. control (17.84 ± 3.31 vs. 6.44 ± 1.13, p = 0.001). Our results suggest that DEHP is more efficiently converted to MEHP in girls with PT, the importance of which needs to be further elucidated.

KEYWORDS:

Mono-(2-ethylhexyl) phthalate; Phthalate; Premature thelarche; di-(2-ethylhexyl) phthalate

PMID:
29625387
DOI:
10.1016/j.etap.2018.03.010
[Indexed for MEDLINE]

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