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Ocul Surf. 2018 Jul;16(3):314-321. doi: 10.1016/j.jtos.2018.04.001. Epub 2018 Apr 4.

Ocular chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation in an Italian referral center.

Author information

1
Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy. Electronic address: berchicci.luigi@hsr.it.
2
Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.
3
Medical Physics Department, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.

Abstract

PURPOSE:

This study aimed to assess the prevalence and clinical manifestations of ocular graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).

METHODS:

269 patients who received allo-HSCT for hematologic malignancies were evaluated between December 2013 and April 2017 in this prospective observational study. Subjects underwent ophthalmologic examination at 6, 12 and 24 months after allo-HSCT. We evaluated the ophthalmologic and hematological data using the NIH consensus criteria definition and the International Chronic Ocular GVHD Consensus Group scoring systems.

RESULTS:

According to NIH consensus criteria definition, ocular GVHD developed in 46.1%, 51.9% and 54.7% of patients at the follow-up visits. According to the International Chronic Ocular GVHD Consensus Group, ocular GVHD developed in 41.3%, 47.7% and 51.9% of patients at the follow-up visits. We found a strong association between the presence of systemic GVHD and the development of chronic ocular GVHD throughout the entire follow-up period. Weaker associations were found between the presence of a female donor, matched related donor, conjunctival hyperemia and conjunctival fibrosis.

CONCLUSIONS:

More than 50% of subjects develop chronic ocular GVHD after allo-HSCT. The presence of active systemic GVHD, female donor and matched related donor are associated with ocular GVHD development.

KEYWORDS:

Dry eye disease; Hematopoietic stem cell transplantation; Ocular graft-versus-host disease

PMID:
29625303
DOI:
10.1016/j.jtos.2018.04.001
[Indexed for MEDLINE]

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