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Cell Stem Cell. 2018 Apr 5;22(4):589-599.e5. doi: 10.1016/j.stem.2018.03.015.

Human Hippocampal Neurogenesis Persists throughout Aging.

Author information

1
Department of Psychiatry, Columbia University, New York, NY 10032, USA; Division of Molecular Imaging and Neuropathology, NYS Psychiatric Institute, New York, NY 10032, USA. Electronic address: mb928@cumc.columbia.edu.
2
Division of Molecular Imaging and Neuropathology, NYS Psychiatric Institute, New York, NY 10032, USA.
3
Division of Integrative Neuroscience, NYS Psychiatric Institute, New York, NY 10032, USA.
4
Institute for Forensic Medicine, Ss. Cyril & Methodius University, Skopje 1000, Republic of Macedonia.
5
Department of Psychiatry, Columbia University, New York, NY 10032, USA; Division of Molecular Imaging and Neuropathology, NYS Psychiatric Institute, New York, NY 10032, USA; Macedonian Academy of Sciences & Arts, 2, Ss. Cyril & Methodius University, Skopje 1000, Republic of Macedonia.
6
Department of Psychiatry, Columbia University, New York, NY 10032, USA; Division of Molecular Imaging and Neuropathology, NYS Psychiatric Institute, New York, NY 10032, USA.
7
Department of Psychiatry, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA; Division of Molecular Imaging and Neuropathology, NYS Psychiatric Institute, New York, NY 10032, USA; Macedonian Academy of Sciences & Arts, 2, Ss. Cyril & Methodius University, Skopje 1000, Republic of Macedonia.
8
Department of Psychiatry, Columbia University, New York, NY 10032, USA; Department of Neuroscience, Columbia University, New York, NY 10032, USA; Department of Pharmacology, Columbia University, New York, NY 10032, USA; Division of Integrative Neuroscience, NYS Psychiatric Institute, New York, NY 10032, USA.

Abstract

Adult hippocampal neurogenesis declines in aging rodents and primates. Aging humans are thought to exhibit waning neurogenesis and exercise-induced angiogenesis, with a resulting volumetric decrease in the neurogenic hippocampal dentate gyrus (DG) region, although concurrent changes in these parameters are not well studied. Here we assessed whole autopsy hippocampi from healthy human individuals ranging from 14 to 79 years of age. We found similar numbers of intermediate neural progenitors and thousands of immature neurons in the DG, comparable numbers of glia and mature granule neurons, and equivalent DG volume across ages. Nevertheless, older individuals have less angiogenesis and neuroplasticity and a smaller quiescent progenitor pool in anterior-mid DG, with no changes in posterior DG. Thus, healthy older subjects without cognitive impairment, neuropsychiatric disease, or treatment display preserved neurogenesis. It is possible that ongoing hippocampal neurogenesis sustains human-specific cognitive function throughout life and that declines may be linked to compromised cognitive-emotional resilience.

KEYWORDS:

Ki-67; NeuN; PSA-NCAM; Sox2; dentate gyrus; doublecortin; granule cells; nestin; neural progenitor; volume

PMID:
29625071
PMCID:
PMC5957089
DOI:
10.1016/j.stem.2018.03.015
[Indexed for MEDLINE]
Free PMC Article

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