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Liver Transpl. 2018 Jun;24(6):831-840. doi: 10.1002/lt.25072.

Should organs from hepatitis C-positive donors be used in hepatitis C-negative recipients for liver transplantation?

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Multiorgan Transplant Program, University of Toronto, Toronto, Canada.
Liver Transplantation and Hepatology Unit, La Fe University Hospital, Universidad de Valencia, Valencia, Spain.

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Given the scarcity of donated organs and the frequency of death on the waiting list, strategies that could improve the available supply of high-quality liver grafts are much needed. Direct-acting antiviral agent (DAA) regimens have proved to be highly effective to treat hepatitis C virus (HCV), even in the setting of posttransplantation. The question arises as to whether transplant communities should consider the utilization of HCV-positive donors into HCV-negative recipients. This review summarizes risk of transmission, treatment options with success rate, and ethical considerations for usage of HCV-positive donors. Liver Transplantation 24 831-840 2018 AASLD.

[Indexed for MEDLINE]

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