Send to

Choose Destination
Hum Vaccin Immunother. 2018;14(8):1970-1976. doi: 10.1080/21645515.2018.1460986. Epub 2018 May 14.

The immunization status of children with chronic neurological disease and serological assessment of vaccine-preventable diseases.

Author information

a Eskisehir Osmangazi University Faculty of Medicine , Department of Social Pediatrics , Eskisehir , Turkey.
b Eskisehir Osmangazi University Faculty of Medicine , Department of Pediatric Neurology , Eskisehir , Turkey.
c Eskisehir Osmangazi University Faculty of Medicine , Department of Pediatric Infectious Disease , Eskisehir , Turkey.
d Eskisehir Osmangazi University Faculty of Medicine , Department of Pediatric Intensive Care Unit , Eskisehir , Turkey.


The aim of this study was to evaluate the age-appropriate immunization coverage in 366 children with chronic neurological disease (CND), to evaluate the use of vaccines not included in routine program, to evaluate serological tests for vaccine-preventable diseases and to describe the related factors in unvaccinated children. 95.6% of all children with had received age-appropriate vaccinations according to the actual National Immunization Program (NIP) during childhood. 12 children (3.6%) had not received vaccines; only two had true contraindications. Because most of the vaccines have been implemented through the NIP for 10 years in Turkey, 88% of children required these new vaccines or booster doses. Moreover, 86.6% of the children and 92.6% of household contacts had no prior history of influenza vaccine. Furthermore, 88% of the patients had not received the varicella vaccine, and the anti-varicella IgG levels were only negative in 27.9%. In addition, 18.6% of the children were negative for anti-mumps IgG, 23.7% for anti-measles IgG, and 6.3% for anti-rubella IgG. Anti-HBs IgG level was 0-10 IU/L in 45.6% of the patients (most of them previously vaccinated) and 79.8% were negative for hepatitis A IgG antibodies. For pertussis infection, the antibody titers of 54.1% of patients were below the protective level, and 10% of patients had a prior acute pertussis infection. Therefore, it is suggested that children with CND should be evaluated for their vaccination status during their first and follow-up visits at certain intervals, and their primary immunization should be completed; moreover, many will need revaccination or booster doses.


chronic neurological disease; vaccination

[Available on 2019-05-14]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center