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J Am Chem Soc. 2018 Apr 25;140(16):5421-5426. doi: 10.1021/jacs.8b00254. Epub 2018 Apr 11.

Well-Defined Oligo- and Polysaccharides as Ideal Probes for Structural Studies.

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Department of Biomolecular Systems , Max Planck Institute of Colloids and Interfaces , Am Mühlenberg 1 , 14476 Potsdam , Germany.
Institute of Chemistry and Biochemistry , Freie Universität Berlin , Arnimallee 22 , 14195 Berlin , Germany.
CIC bioGUNE , Bizkaia Science and Technology Park bld 801 A , 48160 Derio , Bizkaia , Spain.


Polysaccharides are the most abundant organic materials in nature, yet correlations between their three-dimensional structure and macroscopic properties have not been established. Automated glycan assembly enables the preparation of well-defined oligo- and polysaccharides resembling natural as well as unnatural structures. These synthetic glycans are ideal probes for the fundamental study of polysaccharides. According to molecular modeling simulations and NMR analysis, different classes of polysaccharides adopt fundamentally different conformations that are drastically altered by single-site substitutions. Larger synthetic polysaccharides are obtained via a "LEGO"-like approach as a first step toward the production of tailor-made carbohydrate-based materials.


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