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Rev Med Inst Mex Seguro Soc. 2018;56(Suppl 1):S6-S11.

Relationship between bone remodeling and metabolism in the elderly

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Instituto Mexicano del Seguro Social, Coordinación de Investigación en Salud, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Unidad de Investigación Médica en Enfermedades Endócrinas. Ciudad de México, México lbasurtoa@yahoo.com

Abstract

in English, Spanish

Background:

Recent studies have shown that osteocalcin (OC) is related to not only bone metabolism but also energy metabolism. The aim of the present study was to investigate whether OC was associated with metabolic factors and bone mineral density (BMD) in elderly men.

Methods:

A cross-sectional study was done including 122 healthy men aged 60 years or older. Serum glucose, lipids, insulin, adiponectin and OC were measured and BMD was estimated using dual energy X-ray absorptiometry.

Results:

42.8% of men had metabolic syndrome (MetS). OC levels were not significantly different between men with and without MetS. OC concentrations were inversely associated with body mass index (BMI) (r = −0.226, p = 0.04), waist circumference (r = −0.261, p = 0.02), glucose (r = −0.245, p = 0.03), insulin (r = −0.235, p = 0.03), and HOMA-IR (r = −0.211, p = 0.04). In addition, OC levels were higher in patients with diminished BMD compared with those with normal BMD.

Conclusions:

OC levels correlate negatively with BMI, waist circumference, glucose, insulin and HOMA-IR in elderly men, which suggests a connection between bone and energy metabolism.

KEYWORDS:

Osteocalcin; Aged; Metabolic Syndrome; Bone Density

PMID:
29624339
[Indexed for MEDLINE]

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