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SAGE Open Med. 2018 Mar 26;6:2050312118762042. doi: 10.1177/2050312118762042. eCollection 2018.

Altered immunoglobulins (A and G) in Ghanaian patients with type 2 diabetes.

Author information

1
Department of Chemical Pathology, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.
2
Department of Physician Assistant Studies, University of Cape Coast, Cape Coast, Ghana.
3
Department of Physiology, University of Lausanne, Lausanne, Switzerland.
4
Department of Microbiology, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.
5
Central Laboratory Sub-BMC unit, Korle-Bu Teaching Hospital, Accra, Ghana.
6
Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.

Abstract

Objectives:

Elevated immunoglobulin levels have been strongly linked to the development and progression of inflammatory disorders such as type 2 diabetes and obesity. This study aimed to evaluate circulating immunoglobulin levels and to identify other metabolic factors that influence humoral immune response among Ghanaian subjects with type 2 diabetes.

Methods:

A comparative cross-sectional study conducted at the National Diabetes Management and Research Center, Accra. Eighty persons with type 2 diabetes were age-matched with 78 controls. Immunoglobulin A, immunoglobulin G and immunoglobulin M; interleukin 6; fasting blood glucose; glycated hemoglobin; and lipid parameter concentrations were measured. Blood pressure, anthropometry and body composition indices were also assessed.

Results:

Median immunoglobulin A and immunoglobulin G (g/L) levels were higher in the case group compared with controls (0.89 vs 0.74, p = 0.043; 7.58 vs 7.29, p < 0.001). Immunoglobulin G, immunoglobulin A and interleukin 6 levels in the case cohort, respectively, associated weakly with fasting blood glucose (r = 0.252, p = 0.001; r = 0.170, p = 0.031; r = 0.296, p = 0.001). There were positive correlations within the control group for immunoglobulin A versus interleukin 6 (r = 0.366, p = 0.001) and within the case group for glycated hemoglobin versus interleukin 6 (r = 0.190, p = 0.020).

Conclusion:

Our data suggest that humoral immune response is altered in subjects with type 2 diabetes and that serum immunoglobulin levels could serve as useful biomarkers in the investigation and management of diabetes mellitus.

KEYWORDS:

Immunoglobulin; interleukin; type 2 diabetes

Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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