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Clin Endosc. 2018 May;51(3):266-273. doi: 10.5946/ce.2017.109. Epub 2018 Apr 6.

Characteristics of Synchronous and Metachronous Multiple Gastric Tumors after Endoscopic Submucosal Dissection of Early Gastric Neoplasm.

Author information

1
Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
2
Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.

Abstract

Background/Aims:

Endoscopic submucosal dissection (ESD) has been widely accepted as a method of treatment of early gastric tumor. This study aimed to identify the incidence and characteristics of multiple gastric tumors after ESD.

METHODS:

Patients with early gastric tumors who were treated by ESD from January 2004 to June 2012 and followed up with endoscopic examination periodically for at least 1 year were enrolled. All multiple gastric lesions were subsequently treated with ESD and the medical records of the patients were retrospectively reviewed.

RESULTS:

In total, 643 patients were included. The mean duration of endoscopic follow-up was 45.27±27.59 (range, 12-148) months. Overall, 144 patients (22.4%) showed multiple gastric tumors during the follow-up period (44 synchronous [6.8%] and 100 metachronous [15.5%]). The cumulative incidence rate steadily increased during the follow-up period. More than 50% of the tumors that developed at the same longitudinal location of the stomach were of the same macroscopic and histological type as the primary lesions.

Conclusions:

Because synchronous and/or metachronous gastric tumors are common, considerable attention should be paid to detect multiple gastric lesions after ESD of early gastric neoplasm.

KEYWORDS:

Endoscopic submucosal dissection; Neoplasms, second primary; Stomach neoplasms

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