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Am J Ophthalmol. 2018 Jul;191:23-33. doi: 10.1016/j.ajo.2018.03.038. Epub 2018 Apr 3.

Long-term Choroidal Thickness Changes in Eyes With Drusenoid Pigment Epithelium Detachment.

Author information

1
Vitreous Retina Macula Consultants of New York, New York, New York, USA; LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, USA; Unit of Macula, Oftalvist Clinic, Valencia, Spain.
2
Vitreous Retina Macula Consultants of New York, New York, New York, USA; LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, USA; Department of Physiology and Pharmacology, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia; Department of Ophthalmology, Sir Charles Gairdner Hospital, Perth, Australia.
3
Vitreous Retina Macula Consultants of New York, New York, New York, USA; LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, USA; Department of Ophthalmology, Bordeaux Hospital, Bordeaux, France.
4
Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, New York, USA; Biostatistics Unit, Feinstein Institute for Medical Research, Northwell Health, Great Neck, New York, USA.
5
Vitreous Retina Macula Consultants of New York, New York, New York, USA; LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, USA.
6
Vitreous Retina Macula Consultants of New York, New York, New York, USA; LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, USA; Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, New York, USA; Department of Ophthalmology, New York University School of Medicine, New York, New York, USA. Electronic address: kbfnyf@aol.com.

Abstract

PURPOSE:

To analyze the changes in visual acuity and subfoveal choroidal thickness in patients with non-neovascular age-related macular degeneration (AMD) and drusenoid pigment epithelium detachments (PED).

DESIGN:

Consecutive observational case series.

METHODS:

Observational retrospective review of eyes diagnosed with drusenoid PED in a single clinical setting. Demographic and clinical data included age, sex, laterality, best-corrected visual acuity (BCVA), and subfoveal choroidal thickness measured at baseline. before and after the collapse of the PED, and at the last available follow-up. The presence of geographic atrophy (GA) was also assessed.

RESULTS:

Thirty-seven eyes of 25 patients (18 female) were included in the analysis. Mean age at baseline was 71 ± 8.4 years. During a mean follow-up period of 4.9 ±1.9 years, PED collapse was observed in 25 eyes (68%). Mean BCVA, mean maximum PED height, and mean subfoveal choroidal thickness significantly decreased from baseline to the last available follow-up (P < .001) in patients showing PED collapse. Choroidal thinning was faster during the PED collapse (speed rate of 35.9 μm/year). From those, 23 eyes (92%) developed GA. A significant correlation between the area of GA and the decrease in choroidal thickness was found (P = .010).

CONCLUSIONS:

Choroidal thickness significantly decreased in eyes showing drusenoid PED collapse, but not in eyes in which the PED persisted. A significant correlation with resultant GA area following PED collapse and the magnitude of choroidal thinning was found. Further studies are warranted to better understand the mechanisms involved in the occurrence of choroidal changes during the life cycle of drusenoid PEDs.

PMID:
29621509
DOI:
10.1016/j.ajo.2018.03.038

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