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Neuron. 2018 Apr 4;98(1):31-48. doi: 10.1016/j.neuron.2018.02.022.

Regulation of Body Temperature by the Nervous System.

Author information

1
Department of Physiology, University of California, San Francisco, San Francisco, CA 94158.
2
Department of Physiology, University of California, San Francisco, San Francisco, CA 94158; Kavli Center for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158. Electronic address: zachary.knight@ucsf.edu.

Abstract

The regulation of body temperature is one of the most critical functions of the nervous system. Here we review our current understanding of thermoregulation in mammals. We outline the molecules and cells that measure body temperature in the periphery, the neural pathways that communicate this information to the brain, and the central circuits that coordinate the homeostatic response. We also discuss some of the key unresolved issues in this field, including the following: the role of temperature sensing in the brain, the molecular identity of the warm sensor, the central representation of the labeled line for cold, and the neural substrates of thermoregulatory behavior. We suggest that approaches for molecularly defined circuit analysis will provide new insight into these topics in the near future.

KEYWORDS:

brown-fat thermogenesis; calcium imaging; dorsomedial hypothalamus; neural circuit; optogenetics; preoptic area; shivering; sweating; vasodilation; warm sensor; warm-sensitive neurons

PMID:
29621489
PMCID:
PMC6034117
DOI:
10.1016/j.neuron.2018.02.022
[Indexed for MEDLINE]
Free PMC Article

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