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Neuron. 2018 Apr 4;98(1):192-207.e10. doi: 10.1016/j.neuron.2018.02.019.

A Hypothalamic Midbrain Pathway Essential for Driving Maternal Behaviors.

Author information

1
Neuroscience Institute, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
2
Neuroscience Institute, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA; Department of Psychiatry, New York University School of Medicine, 1 Park Avenue, New York, NY 10016, USA; Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA. Electronic address: dayu.lin@nyumc.org.

Abstract

Maternal behaviors are essential for the survival of the young. Previous studies implicated the medial preoptic area (MPOA) as an important region for maternal behaviors, but details of the maternal circuit remain incompletely understood. Here we identify estrogen receptor alpha (Esr1)-expressing cells in the MPOA as key mediators of pup approach and retrieval. Reversible inactivation of MPOAEsr1+ cells impairs those behaviors, whereas optogenetic activation induces immediate pup retrieval. In vivo recordings demonstrate preferential activation of MPOAEsr1+ cells during maternal behaviors and changes in MPOA cell responses across reproductive states. Furthermore, channelrhodopsin-assisted circuit mapping reveals a strong inhibitory projection from MPOAEsr1+ cells to ventral tegmental area (VTA) non-dopaminergic cells. Pathway-specific manipulations reveal that this projection is essential for driving pup approach and retrieval and that VTA dopaminergic cells are reliably activated during those behaviors. Altogether, this study provides new insight into the neural circuit that generates maternal behaviors.

KEYWORDS:

dopamine; electrophysiology; estrogen receptor alpha; hypothalamus; maternal behaviors; medial preoptic area; neural circuit; optogenetics; pup retrieval; ventral tegmental area

PMID:
29621487
PMCID:
PMC5890946
DOI:
10.1016/j.neuron.2018.02.019
[Indexed for MEDLINE]
Free PMC Article

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