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JAMA Facial Plast Surg. 2018 Sep 1;20(5):367-372. doi: 10.1001/jamafacial.2018.0230.

Novel Use of a Volumizing Hyaluronic Acid Filler for Treatment of Infraorbital Hollows.

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Buckingham Center for Facial Plastic Surgery, Austin, Texas.



Hyaluronic acid filler can be safely used as a soft-tissue filler for correction of infraorbital hollowing. It has a high overall patient satisfaction profile among patients.


To report safety and patient satisfaction outcomes of Juvéderm Voluma XC for correction of infraorbital hollows.

Design, Setting, and Patients:

This was a retrospective observational study performed at a private ambulatory facial plastic and reconstructive surgery practice. Participants were all patients 21 to 85 years old who presented to our practice and underwent Juvéderm Voluma XC treatment for correction of infraorbital hollows as a singular intervention from February 2016 to March 2017.


Injection of Juvéderm Voluma XC to the tear trough, nasojugal fold, and/or palpebromalar groove.

Main Outcomes and Measures:

Primary outcome measures include the number of recorded short- and long-term adverse events, need for additional treatment, and patient questionnaire FACE-Q scores.


A total of 202 eyes were treated in 101 patients with a mean follow-up of 12 months. Patients were principally female (90 [89%]) with an average age of 54 years (range, 21-85 years). Most patients (99) had Fitzpatrick grade 1 to 4 skin type (98%) and had an infraorbital hollows score of 2 to 4 (89 [88%]). The average initial treatment volume was 1 mL with 18 patients (18%) requiring additional treatment within 3 months. The average time until additional treatment was 35.7 days. Adverse effects include bruising (in 10 [10%], contour irregularities (2 [2%]), swelling (3 [3%]), and Tyndall effect (1 [1%]). Hyaluronidase was required in 3 patients (3%). Forty-one patients completed the FACE-Q Satisfaction With Eyes survey, and 42 patients completed the FACE-Q Satisfaction With Decision survey (41% and 42%). Overall mean (SD) patient satisfaction (based on FACE-Q scores) was 71.1% (27.3) and 65.6% (31.3), respectively.

Conclusions and Relevance:

Juvéderm Voluma XC has a high patient satisfaction profile and an acceptable safety profile for the correction of infraorbital hollowing.

Level of Evidence:


[Indexed for MEDLINE]
Free PMC Article

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