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Environ Sci Pollut Res Int. 2018 Apr 4. doi: 10.1007/s11356-018-1880-y. [Epub ahead of print]

Toxicological evaluation of nail polish waste discarded in the environment.

Author information

1
Department of Biophysics and Biometry, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.
2
Faculty of Pharmacy, Federal University of Goiás (UFG), Goiânia, GO, Brazil.
3
Department of Pharmacy and Pharmaceutical Administration, Pharmacy College, Fluminense Federal University, Rua Mário Viana, 523, Santa Rosa, CEP 24, Niterói, RJ, 241-000, Brazil.
4
Department of Organic Chemistry, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.
5
Department of Genetics, Federal University of Paraná (UFPR), Curitiba, PR, Brazil.
6
Department of Pharmacy and Pharmaceutical Administration, Pharmacy College, Fluminense Federal University, Rua Mário Viana, 523, Santa Rosa, CEP 24, Niterói, RJ, 241-000, Brazil. elisaavelino@id.uff.br.

Abstract

Nail polish has been widely used around the world. However, the hazards of nail polishes discarded in the environment are still poorly investigated. Thus, the toxicogenetic effects of solubilized (SE) and leached (LE) extracts from nail polishes were investigated, simulating their disposal on water and landfill, respectively, and identifying their physicochemical properties and chemical constituents. Organic compounds and metals were detected in both extracts. SE and LE only induced mutagenic effects in TA98 Salmonella strain in the presence and absence of exogenous metabolic activation. Although both extracts did not significantly increase the frequency of micronucleated HepG2 cells, the cell viability was affected by 24-h exposure. No DNA damage was observed in gonad fish cells (RTG-2) exposed to both extracts; however, the highest SE and LE concentrations induced significant lethal and sublethal effects on zebrafish early-life stages during 96-h exposure. Based on our findings, it can be concluded that if nail polishes enter aquatic systems, it may cause negative impacts to the environment.

KEYWORDS:

Cytotoxicity; Ecotoxicity; Embryotoxicity; Environment; Genotoxicity; Leached extract; Mutagenicity; Nail polishes waste; Solubilized extract

PMID:
29619636
DOI:
10.1007/s11356-018-1880-y

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