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Front Oncol. 2018 Mar 21;8:78. doi: 10.3389/fonc.2018.00078. eCollection 2018.

The Predictive Value of Inflammation-Related Peripheral Blood Measurements in Cancer Staging and Prognosis.

Author information

1
VA Palo Alto Health Care System, Palo Alto, CA, United States.
2
Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, OR, United States.
3
Canary Center at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, CA, United States.
4
Department of Radiation Medicine, Oregon Health & Science University, Portland, OR, United States.
5
Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR, United States.
6
Cancer Early Detection & Advanced Research Center, Oregon Health & Science University, Portland, OR, United States.
7
Knight Cancer Institute, Oregon Health & Science University, Portland, OR, United States.
8
Department of Surgery, Stanford University School of Medicine, Stanford, CA, United States.
9
Department of Urology, Stanford University School of Medicine, Stanford, CA, United States.

Abstract

In this review, we discuss the interaction between cancer and markers of inflammation (such as levels of inflammatory cells and proteins) in the circulation, and the potential benefits of routinely monitoring these markers in peripheral blood measurement assays. Next, we discuss the prognostic value and limitations of using inflammatory markers such as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios and C-reactive protein measurements. Furthermore, the review discusses the benefits of combining multiple types of measurements and longitudinal tracking to improve staging and prognosis prediction of patients with cancer, and the ability of novel in silico frameworks to leverage this high-dimensional data.

KEYWORDS:

C-reactive protein; biomarkers; cancer; longitudinal; neutrophil-to-lymphocyte; platelet-to-lymphocyte; prognosis

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