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Nat Rev Mol Cell Biol. 2018 Jun;19(6):349-364. doi: 10.1038/s41580-018-0003-4.

Mechanism and medical implications of mammalian autophagy.

Author information

1
Institute of Biochemistry II, School of Medicine, Goethe University, Frankfurt am Main, Germany. Ivan.Dikic@biochem2.de.
2
Buchmann Institute for Molecular Life Sciences, Goethe University, Frankfurt am Main, Germany. Ivan.Dikic@biochem2.de.
3
Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel. Zvulun.Elazar@weizmann.ac.il.

Abstract

Autophagy is a highly conserved catabolic process induced under various conditions of cellular stress, which prevents cell damage and promotes survival in the event of energy or nutrient shortage and responds to various cytotoxic insults. Thus, autophagy has primarily cytoprotective functions and needs to be tightly regulated to respond correctly to the different stimuli that cells experience, thereby conferring adaptation to the ever-changing environment. It is now apparent that autophagy is deregulated in the context of various human pathologies, including cancer and neurodegeneration, and its modulation has considerable potential as a therapeutic approach.

PMID:
29618831
DOI:
10.1038/s41580-018-0003-4

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