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Nature. 2018 Apr;556(7700):197-202. doi: 10.1038/s41586-018-0012-7. Epub 2018 Apr 4.

The evolutionary history of vertebrate RNA viruses.

Author information

1
State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
2
Shanghai Public Health Clinical Center & Institute of Biomedical Sciences, Fudan University, Shanghai, China.
3
Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
4
Wenzhou Center for Disease Control and Prevention, Wenzhou, China.
5
College of Marine Sciences, South China Agricultural University, Guangzhou, China.
6
Wuhan Center for Disease Control and Prevention, Wuhan, China.
7
Yancheng Center for Disease Control and Prevention, Yancheng, China.
8
State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. zhangyongzhen@shphc.org.cn.
9
Shanghai Public Health Clinical Center & Institute of Biomedical Sciences, Fudan University, Shanghai, China. zhangyongzhen@shphc.org.cn.

Abstract

Our understanding of the diversity and evolution of vertebrate RNA viruses is largely limited to those found in mammalian and avian hosts and associated with overt disease. Here, using a large-scale meta-transcriptomic approach, we discover 214 vertebrate-associated viruses in reptiles, amphibians, lungfish, ray-finned fish, cartilaginous fish and jawless fish. The newly discovered viruses appear in every family or genus of RNA virus associated with vertebrate infection, including those containing human pathogens such as influenza virus, the Arenaviridae and Filoviridae families, and have branching orders that broadly reflected the phylogenetic history of their hosts. We establish a long evolutionary history for most groups of vertebrate RNA virus, and support this by evaluating evolutionary timescales using dated orthologous endogenous virus elements. We also identify new vertebrate-specific RNA viruses and genome architectures, and re-evaluate the evolution of vector-borne RNA viruses. In summary, this study reveals diverse virus-host associations across the entire evolutionary history of the vertebrates.

PMID:
29618816
DOI:
10.1038/s41586-018-0012-7
[Indexed for MEDLINE]

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