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BMC Cancer. 2018 Apr 3;18(1):372. doi: 10.1186/s12885-018-4253-5.

Compared characteristics of current vs. past smokers at the time of diagnosis of a first-time lung or head and neck cancer: a cross-sectional study.

Author information

1
Service de Tabacologie, Clinique de Pneumologie, Hôpital Calmette, CHRU de Lille CS70001, 59037, Lille cedex, France. corinne.vannimenus@chru-lille.fr.
2
Centre de Référence Régionale en Cancérologie, Lille, France.
3
Service de Tabacologie, Clinique de Pneumologie, Hôpital Calmette, CHRU de Lille CS70001, 59037, Lille cedex, France.
4
Service d'Oto-rhino-laryngologie, CHRU de Lille, Lille, France.
5
Département de Cancérologie Cervico-Faciale, Centre de Lutte Contre le Cancer Oscar Lambret, Lille, France.
6
Service d'Addictologie, CHRU de Lille, Lille, France.
7
Clinique de Chirurgie Thoracique, CHRU de Lille, Lille, France.
8
Santé Publique et Epidémiologie, Institut Pasteur, Université de Lille, INSERM UMR744, Lille, France.
9
Univ Lyon; UCBL; INSERM U1028 ; CNRS UMR5292 ; Service Universitaire d'Addictologie de Lyon, CH le Vinatier, Lyon, France.

Abstract

BACKGROUND:

Active smoking at the time of diagnosis of a first head & neck (H&N) or lung cancer is associated with a worse cancer outcome and increased mortality. However, the compared characteristics of active vs. former smokers at cancer diagnosis are poorly known.

METHODS:

In 371 subjects with a first H&N or lung cancer, we assessed: 1) socio-demographic features; 2) lifelong types of smoking; 3) alcohol use disorder identification test (AUDIT); 4) cannabis abuse screening test (CAST); and 5) Mini International Neuropsychiatric Interview (MINI). Using a multivariable regression model, we compared the profile of current smokers and past smokers.

RESULTS:

Current smokers more frequently exhibited H&N cancer (OR 3.91; 95% CI [2.00-6.51]; p <  0.0001) and ever smoking of hand-rolled cigarettes (OR 2.2; 95% CI [1.25-3.88]; p = 0.007). Among subjects with lung cancer (n = 177), current smoking was primarily associated with ever smoking of hand-rolled cigarettes (OR 2.88; 95% CI [1.32-6.30]; p = 0.008) and negatively associated with age (OR 0.92; 95% CI [0.89-0.96]; p <  0.001). Among subjects with H&N cancer (n = 163), current smokers exhibited a significantly greater AUDIT score (OR = 1.08; 95% CI [1.01-1.16]; p = 0.03).

CONCLUSION:

At the time of diagnosis of the first lung or H&N cancer, current smoking is highly associated with previous type of smoking and alcohol drinking patterns.

TRIAL REGISTRATION:

NCT01647425 ; Registration date: July 23, 2012.

KEYWORDS:

Alcohol-related disorders; Head & Neck Neoplasms; Lung neoplasms; Tobacco use

PMID:
29614983
PMCID:
PMC5883294
DOI:
10.1186/s12885-018-4253-5
[Indexed for MEDLINE]
Free PMC Article

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