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J Biomater Sci Polym Ed. 2018 Aug;29(11):1331-1343. doi: 10.1080/09205063.2018.1459351. Epub 2018 Apr 7.

Poly(ethylene glycol)/chitosan/sodium glycerophosphate gel replaced the joint capsule with slow-release lubricant after joint surgery.

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a Key Laboratory for Modern Design & Rotor-Bearing System, Ministry of Education, School of Mechanical Engineering , Xi'an Jiaotong University , Xi'an , P.R. China.
b School of Science , Xi'an Jiaotong University , Xi'an , P.R. China.
c Department of Gynaecology and Obstetrics , The First Affiliated Hospital of Xi'an Jiaotong University, Health Science Center, Xi'an Jiaotong University , Xi'an , P.R. China.


Body fluid is normally the only lubricant after joint replacement surgery, but wear problems have occurred because body fluid has poor lubrication ability. However, traditional lubricant would be diluted by body fluids and then absorbed by the human body. Therefore, an injectable gel with the ability to slow-release lubricant was designed to replace the joint capsule. The proposed gel, poly(ethylene glycol)/chitosan/sodium glycerophosphate (PEG/CS/GP) composite gel was then tested. The tribology results showed that the PEG/CS/GP gel had excellent slow-release properties, especially under pressure, and the PEG played an important role in improving the gel's rheological and mechanical properties. Moreover, this study revealed that the release solution had a good lubrication effect because the PEG and GP could crosslink via the hydrogen bond effect.


Chitosan; artificial joints; lubricant; poly(ethylene glycol); slow-release; sodium glycerophosphate

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