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Adv Mater. 2018 May;30(21):e1707408. doi: 10.1002/adma.201707408. Epub 2018 Apr 2.

Directed Nanoscale Self-Assembly of Low Molecular Weight Hydrogelators Using Catalytic Nanoparticles.

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Advanced Soft Matter Group, Department of Chemical Engineering, Delft University of Technology, van der Maasweg 9, 2629, HZ, Delft, The Netherlands.
State-Key Laboratory of Chemical Engineering, East China University of Science and Technology, Meilong Road 130, 200237, Shanghai, P. R. China.


The work presented here shows that the growth of supramolecular hydrogel fibers can be spatially directed at the nanoscale by catalytic negatively charged nanoparticles (NCNPs). The NCNPs with surfaces grafted with negatively charged polymer chains create a local proton gradient that facilitates an acid-catalyzed formation of hydrogelators in the vicinity of NCNPs, ultimately leading to the selective formation of gel fibers around NCNPs. The presence of NCNPs has a dominant effect on the properties of the resulting gels, including gelation time, mechanical properties, and network morphology. Interestingly, local fiber formation can selectively entrap and precipitate out NCNPs from a mixture of different nanoparticles. These findings show a new possibility to use directed molecular self-assembly to selectively trap target nano-objects, which may find applications in therapy, such as virus infection prevention, or engineering applications, like water treatment and nanoparticle separation.


gels; local catalysis; low molecular weight gelators; nanofibers; self-assembly


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