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Immunol Res. 2018 Jun;66(3):348-354. doi: 10.1007/s12026-018-8993-8.

Tumor necrosis factor gene polymorphisms are associated with systemic lupus erythematosus susceptibility or lupus nephritis in Mexican patients.

Author information

1
Unidad de Investigación en Investigación en Enfermedades Metabólicas y Endócrinas, Hospital Juárez de México, Mexico City, Mexico. dr.julian.ramirez.hjm@gmail.com.
2
Instituto Politécnico Nacional, Gustavo A. Madero, Magdalena de Las Salinas, 07760, Mexico City, Mexico. dr.julian.ramirez.hjm@gmail.com.
3
Unidad de Investigación en Investigación en Enfermedades Metabólicas y Endócrinas, Hospital Juárez de México, Mexico City, Mexico.
4
Programa de Doctorado de la Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico.
5
Laboratorio de Oncología Molecular, Unidad de Diferenciacón Celular y Cáncer, FES-Zaragoza, UNAM, Mexico City, Mexico.
6
Servicio de Reumatología, Hospital Juárez de México, Mexico City, Mexico.
7
Departamento de Inmunología, Instituto Nacional de Cardiología, Mexico City, Mexico.
8
Laboratorio de Diagnóstico Molecular y Genética, Hospital Juárez de México, Mexico City, Mexico.
9
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.

Abstract

The TNF -238G/A (rs361525) and -308G/A (rs1800629) polymorphisms have consistently been associated with systemic lupus erythematosus (SLE) in several populations; however, these findings have not been verified in all populations. Here, we aimed to examine whether the TNF -238G/A, -308G/A, -376G/A (rs1800750), and -1031T/C (rs1799964) polymorphisms confer SLE or lupus nephritis (LN) susceptibility in a Mexican population. Our study included 442 patients with SLE and 495 controls. For genotyping, we used the TaqMan 5' allele discrimination assay. The TNF -238G/A and -1031T/C polymorphisms were associated with SLE susceptibility (odds ratio (OR) 2.1, p = 0.0005 and OR 1.4, p = 0.003, respectively). Gender stratification showed a strong association between TNF -238G/A and SLE in women (OR 2.2, p = 0.00006), while TNF -1031T/C had an OR of 1.5 (p = 0.007). With regard to the TNF -376G/A polymorphism, this also showed association with SLE susceptibility (OR 1.95, p = 0.036) and LN (OR 3.5, p = 0.01). In conclusion, our study provides the first demonstration of association between the TNF -376G/A polymorphism and SLE and LN susceptibility. In addition, our study is the second documenting an association of TNF -1031T/C with SLE susceptibility. We also observed a strong association between TNF -238G/A and SLE susceptibility. The TNF 308G/A polymorphism was not associated with SLE or LN.

KEYWORDS:

Rheumatoid arthritis; Susceptibility; Systemic lupus erythematosus; Tumor necrosis factor

PMID:
29611038
DOI:
10.1007/s12026-018-8993-8
[Indexed for MEDLINE]

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