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J Bacteriol. 2018 May 24;200(12). pii: e00166-18. doi: 10.1128/JB.00166-18. Print 2018 Jun 15.

Coping with an Essential Poison: a Genetic Suppressor Analysis Corroborates a Key Function of c-di-AMP in Controlling Potassium Ion Homeostasis in Gram-Positive Bacteria.

Author information

1
Department of General Microbiology, Institute of Microbiology and Genetics, GZMB, Georg-August University Göttingen, Germany.
2
Department of General Microbiology, Institute of Microbiology and Genetics, GZMB, Georg-August University Göttingen, Germany jstuelk@gwdg.de.

Abstract

Cyclic di-AMP (c-di-AMP) is an important second messenger in bacteria. In most Firmicutes, the molecule is required for growth in complex media but also toxic upon accumulation. In an article on their current study, Zarrella and coworkers present a suppressor analysis of a Streptococcus pneumoniae strain that is unable to degrade c-di-AMP (T. M. Zarrella, D. W. Metzger, and G. Bai, J Bacteriol 200:e00045-18, 2018, https://doi.org/10.1128/JB.00045-18). Their study identifies new links between c-di-AMP and potassium homeostasis and supports the hypothesis that c-di-AMP serves as a second messenger to report about the intracellular potassium concentrations.

KEYWORDS:

Streptococcus pneumoniae; diadenylate cyclase; phosphodiesterase; potassium uptake; second messenger

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