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J Clin Sleep Med. 2018 Apr 15;14(4):697-699. doi: 10.5664/jcsm.7078.

Segmental Hair Testing of Triazolam to Unmask a Suspected Case of Idiopathic Recurrent Stupor.

Author information

1
Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
2
IRCCS Istituto delle Scienze Neurologiche, AUSL di Bologna, Bologna, Italy.
3
Drug Abuse and Doping Unit, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Rome, Italy.
4
National Centre on Addiction and Doping, Istituto Superiore di Sanità, Rome, Italy.
5
Unit of Forensic Toxicology (UoFT), Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy.

Abstract

Stupor is a diagnostic challenge at emergency department. Differential diagnosis includes idiopathic recurrent stupor, formerly attributed to "endozepine-4" accumulation. This condition has been recently questioned because many suspected cases resulted in exogenous benzodiazepine intake that eludes the conventional toxicological assay. In case of unexplained recurrent stupor, to extend the benzodiazepine search in nonconventional matrices can allow unmasking of hidden toxic behavior.

KEYWORDS:

benzodiazepine intoxication; idiopathic recurrent stupor; segmental hair analysis

PMID:
29609715
PMCID:
PMC5886450
DOI:
10.5664/jcsm.7078
[Indexed for MEDLINE]
Free PMC Article

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