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Malar J. 2018 Apr 2;17(1):138. doi: 10.1186/s12936-018-2280-y.

Spatio-temporal dynamic of malaria in Ouagadougou, Burkina Faso, 2011-2015.

Author information

1
Aix Marseille Univ, INSERM, IRD, SESSTIM UMR1252 Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France. boukary.ouedraogo@univ-amu.fr.
2
Aix Marseille Univ, INSERM, IRD, SESSTIM UMR1252 Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.
3
Embassy of Japan in the Republic of Guinea, Conakry, Guinea.
4
Prospective et Coopération, Laboratoire d'Idées, Bureau d'Etudes Recherche, Marseille, France.
5
Ecole des Hautes Etudes en Santé Publique, Rennes, France.
6
Université libre de Bruxelles, EPS, Centre de Recherche en Epidémiologie, Biostatistique et Recherche Clinique, Brussels, Belgium.
7
IRSS-Clinical Research Unit of Nanoro (IRSS-CRUN), Nanoro, Burkina Faso.
8
IRD, UMR 228 ESPACE-DEV, Station SEAS-OI, Saint-Pierre, France.
9
Programme National de Lutte contre le Paludisme, Ministère de la Santé, Ouagadougou, Burkina Faso.
10
Direction Régionale de la Santé du Centre, Ministère de la Santé, Ouagadougou, Burkina Faso.
11
Direction de la Météorologie, Ministère des Transports, Ouagadougou, Burkina Faso.

Abstract

BACKGROUND:

Given the scarcity of resources in developing countries, malaria treatment requires new strategies that target specific populations, time periods and geographical areas. While the spatial pattern of malaria transmission is known to vary depending on local conditions, its temporal evolution has yet to be evaluated. The aim of this study was to determine the spatio-temporal dynamic of malaria in the central region of Burkina Faso, taking into account meteorological factors.

METHODS:

Drawing on national databases, 101 health areas were studied from 2011 to 2015, together with weekly meteorological data (temperature, number of rain events, rainfall, humidity, wind speed). Meteorological factors were investigated using a principal component analysis (PCA) to reduce dimensions and avoid collinearities. The Box-Jenkins ARIMA model was used to test the stationarity of the time series. The impact of meteorological factors on malaria incidence was measured with a general additive model. A change-point analysis was performed to detect malaria transmission periods. For each transmission period, malaria incidence was mapped and hotspots were identified using spatial cluster detection.

RESULTS:

Malaria incidence never went below 13.7 cases/10,000 person-weeks. The first and second PCA components (constituted by rain/humidity and temperatures, respectively) were correlated with malaria incidence with a lag of 2 weeks. The impact of temperature was significantly non-linear: malaria incidence increased with temperature but declined sharply with high temperature. A significant positive linear trend was found for the entire time period. Three transmission periods were detected: low (16.8-29.9 cases/10,000 person-weeks), high (51.7-84.8 cases/10,000 person-weeks), and intermediate (26.7-32.2 cases/10,000 person-weeks). The location of clusters identified as high risk varied little across transmission periods.

CONCLUSION:

This study highlighted the spatial variability and relative temporal stability of malaria incidence around the capital Ouagadougou, in the central region of Burkina Faso. Despite increasing efforts in fighting the disease, malaria incidence remained high and increased over the period of study. Hotspots, particularly those detected for low transmission periods, should be investigated further to uncover the local environmental and behavioural factors of transmission, and hence to allow for the development of better targeted control strategies.

KEYWORDS:

Hotspots; Malaria; Spatial clusters; Spatio-temporal dynamic

PMID:
29609606
PMCID:
PMC5879937
DOI:
10.1186/s12936-018-2280-y
[Indexed for MEDLINE]
Free PMC Article

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