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Anal Bioanal Chem. 2018 May;410(13):3059-3071. doi: 10.1007/s00216-018-0992-z. Epub 2018 Apr 2.

Silicone wristbands compared with traditional polycyclic aromatic hydrocarbon exposure assessment methods.

Author information

1
Food Safety and Environmental Stewardship Program, Environmental and Molecular Toxicology, Oregon State University, 1007 Agricultural and Life Sciences Building, Corvallis, OR, 97331, USA.
2
Columbia Center for Children's Environmental Health, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY, 10032, USA.
3
College of Public Health and Human Sciences, Department of Environmental and Occupational Health, Oregon State University, 160 SW 26th St, Corvallis, OR, 97331, USA.
4
Biological Sciences Division, Pacific Northwest National Laboratory, P.O. Box 999, Richland, WA, 99352, USA.
5
Chemistry and Chemical Engineering Division, Southwest Research Institute, P.O. Drawer 28510, San Antonio, TX, 78228-0510, USA.
6
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, 30333, USA.
7
Food Safety and Environmental Stewardship Program, Environmental and Molecular Toxicology, Oregon State University, 1007 Agricultural and Life Sciences Building, Corvallis, OR, 97331, USA. kim.anderson@oregonstate.edu.

Abstract

Currently there is a lack of inexpensive, easy-to-use technology to evaluate human exposure to environmental chemicals, including polycyclic aromatic hydrocarbons (PAHs). This is the first study in which silicone wristbands were deployed alongside two traditional personal PAH exposure assessment methods: active air monitoring with samplers (i.e., polyurethane foam (PUF) and filter) housed in backpacks, and biological sampling with urine. We demonstrate that wristbands worn for 48 h in a non-occupational setting recover semivolatile PAHs, and we compare levels of PAHs in wristbands to PAHs in PUFs-filters and to hydroxy-PAH (OH-PAH) biomarkers in urine. We deployed all samplers simultaneously for 48 h on 22 pregnant women in an established urban birth cohort. Each woman provided one spot urine sample at the end of the 48-h period. Wristbands recovered PAHs with similar detection frequencies to PUFs-filters. Of the 62 PAHs tested for in the 22 wristbands, 51 PAHs were detected in at least one wristband. In this cohort of pregnant women, we found more significant correlations between OH-PAHs and PAHs in wristbands than between OH-PAHs and PAHs in PUFs-filters. Only two comparisons between PAHs in PUFs-filters and OH-PAHs correlated significantly (rs = 0.53 and p = 0.01; rs = 0.44 and p = 0.04), whereas six comparisons between PAHs in wristbands and OH-PAHs correlated significantly (rs = 0.44 to 0.76 and p = 0.04 to <0.0001). These results support the utility of wristbands as a biologically relevant exposure assessment tool which can be easily integrated into environmental health studies. Graphical abstract PAHs detected in samples collected from urban pregnant women.

KEYWORDS:

Active sampling; Biomonitoring; Environmental toxicology; Exposome; Passive sampling; Personal monitoring

PMID:
29607448
PMCID:
PMC5910488
DOI:
10.1007/s00216-018-0992-z
[Indexed for MEDLINE]
Free PMC Article

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