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Dis Markers. 2018 Feb 11;2018:8735926. doi: 10.1155/2018/8735926. eCollection 2018.

Methylglyoxal: A Relevant Marker of Disease Activity in Patients with Rheumatoid Arthritis.

Author information

1
Laboratory of Biochemistry, LR12ES05, Faculty of Medicine, University of Monastir, Monastir, Tunisia.
2
Laboratory of Biochemistry, University Hospital Tahar Sfar, Mahdia, Tunisia.
3
Department of Rheumatology, University Hospital of Fattouma Bourguiba, Monastir, Tunisia.

Abstract

Background:

The contribution of methylglyoxal (MGO) and soluble receptor for advanced glycation end products (sRAGE) in the presence of rheumatoid arthritis (RA) is still unknown. We investigated whether serum MGO and sRAGE were related to the presence of disease activity in RA.

Methods:

80 patients with RA and 30 control subjects were included in a cross-sectional study. The severity of RA was assessed using the disease activity score for 28 joints (DAS28). Serum MGO and sRAGE were measured by ELISA.

Results:

Serum MGO levels were significantly higher in patients with RA versus control subjects (P < 0.001) and were increased in RA patients with higher disease activity versus RA patients with moderate disease activity (P = 0.019). Serum sRAGE concentrations were significantly decreased in RA patients with higher disease activity versus RA patients with moderate disease activity and versus control subjects (P = 0.004; P = 0.002, resp.). A multiple logistic regression analysis demonstrated that MGO was independently associated with the presence of activity disease in RA (OR = 1.17, 95% CI: 1.02-1.31, P = 0.01).

Conclusion:

Serum MGO and sRAGE levels are inversely related to the activity of RA, and MGO is independently associated with a higher disease activity of RA.

PMID:
29606988
PMCID:
PMC5828101
DOI:
10.1155/2018/8735926
[Indexed for MEDLINE]
Free PMC Article

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