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Case Rep Gastroenterol. 2018 Feb 21;12(1):76-84. doi: 10.1159/000481937. eCollection 2018 Jan-Apr.

Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation.

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Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.
Department of Visceral and Transplantation Surgery, University Hospital RWTH Aachen, Aachen, Germany.
Helmholtz Centre for Infection Research, Braunschweig, Germany.


Clostridium difficile infection (CDI) represents one of the most common healthcare-associated infections. Due to increasing numbers of recurrences and therapy failures, CDI has become a major disease burden. Studies have shown that fecal microbiota transplantation (FMT) can both be a safe and highly efficacious therapy for patients with therapy-refractory CDI. However, patients undergoing solid organ transplantation are at high risk for CDI due to long-term immunosuppression, previous antibiotic therapy, and proton pump inhibitor use. Additionally, these patients may be especially prone to adverse events related to FMT. Here, we report a successful FMT in a patient with severe therapy-refractory CDI after liver transplantation.


Clostridium difficile infection; Fecal microbiota transplantation; Liver transplantation; Microbiota; Pseudomembranous colitis

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