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Case Rep Gastroenterol. 2018 Feb 21;12(1):76-84. doi: 10.1159/000481937. eCollection 2018 Jan-Apr.

Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation.

Author information

1
Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.
2
Department of Visceral and Transplantation Surgery, University Hospital RWTH Aachen, Aachen, Germany.
3
Helmholtz Centre for Infection Research, Braunschweig, Germany.

Abstract

Clostridium difficile infection (CDI) represents one of the most common healthcare-associated infections. Due to increasing numbers of recurrences and therapy failures, CDI has become a major disease burden. Studies have shown that fecal microbiota transplantation (FMT) can both be a safe and highly efficacious therapy for patients with therapy-refractory CDI. However, patients undergoing solid organ transplantation are at high risk for CDI due to long-term immunosuppression, previous antibiotic therapy, and proton pump inhibitor use. Additionally, these patients may be especially prone to adverse events related to FMT. Here, we report a successful FMT in a patient with severe therapy-refractory CDI after liver transplantation.

KEYWORDS:

Clostridium difficile infection; Fecal microbiota transplantation; Liver transplantation; Microbiota; Pseudomembranous colitis

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