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Nephrol Ther. 2018 Apr;14 Suppl 1:S23-S30. doi: 10.1016/j.nephro.2018.02.006.

[Transplantation strategy in type 1 diabetic patients].

[Article in French]

Author information

1
Service de néphrologie, transplantation et immunologie clinique, hôpital Édouard-Herriot, hospices civils de Lyon, place d'Arsonval, 69437 Lyon cedex 3, France.
2
Service d'urologie et de chirurgie de la transplantation, hôpital Édouard-Herriot, hospices civils de Lyon place d'Arsonval, 69437 Lyon cedex 3, France.
3
Service de néphrologie, transplantation et immunologie clinique, hôpital Édouard-Herriot, hospices civils de Lyon, place d'Arsonval, 69437 Lyon cedex 3, France. Electronic address: emmanuel.morelon@chu-lyon.fr.

Abstract

Beta cell replacement by pancreas or Langerhans islets transplantation is the only way to restore glucose homeostasis in type 1 diabetic patients. The counterpart is the need for long-term immunosuppression. These transplantations are therefore mainly indicated for patients candidates for kidney transplantation and for patients with poor quality of life due to unstable diabetes with life-threatening hypoglycemic events. Both beta cell replacement techniques have different benefits and risks and should be adapted to each type 1 diabetic patient. The transplant strategy must be personalized according to parameters assessed in the pre-transplant period, validated by a multidisciplinary team and reassessed regularly until transplantation.

KEYWORDS:

Diabète de type 1; Greffe d’îlots de Langerhans; Kidney transplantation; Langerhans Islet transplantation; Pancreas transplantation; Transplantation de pancréas; Transplantation rénale; Type 1 diabetes

PMID:
29606260
DOI:
10.1016/j.nephro.2018.02.006
[Indexed for MEDLINE]

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