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Thorax. 2018 Dec;73(12):1174-1176. doi: 10.1136/thoraxjnl-2017-211115. Epub 2018 Mar 31.

Association between asthma and lung function in adolescents born very preterm: results of the EPIPAGE cohort study.

Author information

1
Service de Pneumologie et d'Allergologie Pédiatriques, AP-HP, Hôpital Universitaire Necker-Enfants Malades, Paris, France.
2
U955, Equipe 4, INSERM, Créteil, France.
3
Obstetrical, Perinatal, and Pediatric Epidemiology Team, Epidemiology and Biostatistics Sorbonne Paris Cité Research Center (U1153), INSERM, Paris, France.
4
Paris Descartes University, Paris, France.
5
Clinical Research Unit, Center for Clinical Investigation, P1419Cochin Broca Hôtel-Dieu, APHP, Paris, France.
6
Service de Médecine Néonatale, CHU de Nantes, Nantes, France.
7
CIC004, CHU de Nantes, Nantes, France.
8
UMR1027, INSERM, Toulouse, France.
9
Université Paul Sabatier, Toulouse, France.
10
Unité d'épidémiologie clinique, CHU Purpan, Toulouse, France.
11
Unité de Recherche Clinique Cochin-Necker, AP-HP, Paris, France.
12
Unité de Pneumologie et Allergologie pédiatriques & CRCM mixte, Pédiatrie Médicale, CHU Charles Nicolle, Rouen, France.
13
U1245, équipe Neovasc, handicap périnatal neurologique et neuro-protection, INSERM, Rouen, France.
14
IRIB , Faculté de médecine, Université de Rouen, Rouen, France.
15
Unité de Pneumologie et Allergologie pédiatriques, CHU Purpan, Toulouse, France.
16
CRCM Enfants, CHU de Nantes, Nantes, France.

Abstract

Prematurity and bronchopulmonary dysplasia (BPD) affect long-term lung function. We studied the respiratory outcome of adolescents born very preterm and controls from the Etude EPIdémiologique sur les Petits Ages Gestationnels cohort and analysed their current lung function in relation to asthma symptoms (categorised in three age groups) from birth. In models including BPD, asthma at each age and confounding factors in the preterm group, BPD and preschool wheeze were the only independent variables associated with FEV1 Preschool wheeze is an independent factor associated with FEV1 impairment in adolescents born very preterm. These results highlight the need for optimal management of early respiratory symptoms in preterm-born infants. TRIAL REGISTRATION NUMBER: Results, NCT01424553.

KEYWORDS:

paediatric asthma; paediatric lung disaese

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