Format

Send to

Choose Destination
Biomed Pharmacother. 2018 Jun;102:848-854. doi: 10.1016/j.biopha.2018.03.137. Epub 2018 Apr 5.

Peel flour of Passiflora edulis Var. Flavicarpa supplementation prevents the insulin resistance and hepatic steatosis induced by low-fructose-diet in young rats.

Author information

1
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, SC, CEP 88302-202, Brazil.
2
NIQFAR CCS, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, SC, CEP 88302-202, Brazil.
3
Departamento de Nutrição (DNUT) da Universidade Federal de Sergipe (UFS), Avenida Marechal Rondon, s/n - Rosa Elze, São Cristóvão, SE, CEP 49100-000, Brazil.
4
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, SC, CEP 88302-202, Brazil; NIQFAR CCS, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, SC, CEP 88302-202, Brazil.
5
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, SC, CEP 88302-202, Brazil; NIQFAR CCS, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, SC, CEP 88302-202, Brazil. Electronic address: jrs.santin@univali.br.

Abstract

The increase in fructose consumption in the last decades has an important correlation with the growth of overweight population. Fructose is a monosaccharide found in fruits, vegetables and honey, however, it is widely used in processed food and beverages such as sweeteners. This monosaccharide is metabolized in the liver, so it can produce glucose, lactate, triglycerides, free fatty acids and uric acid, which are responsible for negative effects on the liver and extrahepatic tissues. One effect of the high consumption of fructose is the resistance to Insulin, which appears to be an important issue in the development of metabolic abnormalities observed in animals that were subjected to a high fructose diet. The population and, consequently, the market search for natural sources to manage metabolic abnormalities is increasing, but, adequate scientific proof still is necessary. The Passiflora edulis peel flour (PEPF) is a byproduct of the juice industry, and, represents an important source of fiber and bioactive compounds. The present study investigates the PEPF supplementation (30%) effects on insulin sensitivity, adiposity and metabolic parameters in young rats that were given beverages enriched with 10% of fructose for 8 weeks. Fructose intake induced insulin resistance, increased serum triglycerides levels, growth of fat deposits in the liver and widening of the diameter of adipocytes. In contrast, the group that received PEPF did not present such abnormalities, which could be related to the presence of fiber or bioactive compounds (phenolics compounds, e.g., caffeic acid and isoorientin) in its composition, as identified by analytical methods. Thus, for the first time, it has been demonstrated that PEPF supplementation prevents insulin resistance and hepatic steatosis induced by low-fructose-diet in young rats.

KEYWORDS:

Diabetes; Insulin resistance; Liver injury; Passiflora edulis peel flour

PMID:
29605773
DOI:
10.1016/j.biopha.2018.03.137
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center