Format

Send to

Choose Destination
Clin Nutr. 2018 Mar 11. pii: S0261-5614(18)30114-6. doi: 10.1016/j.clnu.2018.03.003. [Epub ahead of print]

Efficacy of cinnamon in patients with type II diabetes mellitus: A randomized controlled clinical trial.

Author information

1
Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Persian Medicine, Faculty of Persian Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2
Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3
Department of Phyopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
4
Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
5
Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mheydari@sums.ac.ir.

Abstract

BACKGROUND & AIMS:

Multiple studies have evaluated the hypoglycemic effect of cinnamon in patients with diabetes mellitus (DM) type II, with conflicting results. Differences in Baseline Body Mass Index (BMI) of patients may be able to explain the observed differences in the results. This study was designed to evaluate the effect of cinnamon supplementation on anthropometric, glycemic and lipid outcomes of patients with DM type II based on their baseline BMI.

METHODS:

The study was designed as a triple-blind placebo-controlled randomized clinical trial, using a parallel design. One hundred and forty patients referred to Diabetes Clinic of Yazd University of Medical Sciences with diagnosis of DM type II were randomly assigned in four groups: cinnamon (BMI ≥ 27, BMI < 27) and Placebo (BMI ≥ 27, BMI < 27). Patients received cinnamon bark powder or placebo in 500 mg capsules twice daily for 3 months. Anthropometric, glycemic and lipid outcomes were measured before and after the intervention.

RESULT:

Cinnamon supplementation led to improvement of all anthropometric (BMI, body fat, and visceral fat), glycemic (FPG, 2hpp, HbA1C, Fasting Insulin, and Insulin Resistance), and lipids (Cholesterol Total, LDL-c and HDL-c) outcomes (except for triglycerides level). All observed changes (except for Cholesterol Total and LDL-c) were significantly more prominent in patients with higher baseline BMI (BMI ≥ 27).

CONCLUSION:

Based on the study findings, cinnamon may improve anthropometric parameters, glycemic indices and lipid profile of patients with type II diabetes. These benefits are significantly more prominent in patients with higher baseline BMI (BMI ≥ 27). The trial protocol was registered in Iranian Registry of Clinical Trials database (registration ID: IRCT2017031133015N1).

KEYWORDS:

Anthropometric parameters; Body Mass Index; Cinnamon; Glycemic indices; Type II diabetes mellitus

PMID:
29605574
DOI:
10.1016/j.clnu.2018.03.003

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center