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Int J Cancer. 2018 Sep 1;143(5):1105-1113. doi: 10.1002/ijc.31413. Epub 2018 Apr 17.

Higher carbohydrate intake is associated with increased risk of all-cause and disease-specific mortality in head and neck cancer patients: results from a prospective cohort study.

Author information

1
Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL.
2
Carle Foundation Hospital, Carle Cancer Center, Urbana, IL.
3
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL.
4
Department of Epidemiology, University of Michigan, Ann Arbor, MI.
5
Department of Health Behavior, University of Alabama at Birmingham, Birmingham, AL.
6
Department of Otolaryngology, University of Alabama at Birmingham, Birmingham, AL.
7
Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL.
8
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI.
9
Department of Otolaryngology, University of Michigan, Ann Arbor, MI.

Abstract

No studies have evaluated associations between carbohydrate intake and head and neck squamous cell carcinoma (HNSCC) prognosis. We prospectively examined associations between pre- and post-treatment carbohydrate intake and recurrence, all-cause mortality, and HNSCC-specific mortality in a cohort of 414 newly diagnosed HNSCC patients. All participants completed pre- and post-treatment Food Frequency Questionnaires (FFQs) and epidemiologic surveys. Recurrence and mortality events were collected annually. Multivariable Cox Proportional Hazards models tested associations between carbohydrate intake (categorized into low, medium and high intake) and time to recurrence and mortality, adjusting for relevant covariates. During the study period, there were 70 deaths and 72 recurrences. In pretreatment analyses, high intakes of total carbohydrate (HR: 2.29; 95% CI: 1.23-4.25), total sugar (HR: 3.03; 95% CI: 1.12-3.68), glycemic load (HR: 2.10; 95% CI: 1.15-3.83) and simple carbohydrates (HR 2.26; 95% CI 1.19-4.32) were associated with significantly increased risk of all-cause mortality compared to low intake. High intakes of carbohydrate (HR 2.45; 95% CI: 1.23-4.25) and total sugar (HR 3.03; 95% CI 1.12-3.68) were associated with increased risk of HNSCC-specific mortality. In post-treatment analyses, medium fat intake was significantly associated with reduced risk of recurrence (HR 0.08; 95% CI 0.01-0.69) and all-cause mortality (HR 0.27; 95% CI 0.07-0.96). Stratification by tumor site and cancer stage in pretreatment analyses suggested effect modification by these factors. Our data suggest high pretreatment carbohydrate intake may be associated with adverse prognosis in HNSCC patients. Clinical intervention trials to further examine this hypothesis are warranted.

KEYWORDS:

carbohydrate; diet; head and neck cancer; laryngeal cancer; mortality; nutrition; oral cancer; oropharyngeal cancer; recurrence; survival

PMID:
29604042
PMCID:
PMC6103810
[Available on 2019-09-01]
DOI:
10.1002/ijc.31413
[Indexed for MEDLINE]

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