Format

Send to

Choose Destination
Regul Toxicol Pharmacol. 2018 Jun;95:254-259. doi: 10.1016/j.yrtph.2018.03.025. Epub 2018 Mar 28.

Neuroprotective effect of the carnosine - α-lipoic acid nanomicellar complex in a model of early-stage Parkinson's disease.

Author information

1
Laboratory of Clinical and Experimental Neurochemistry, Research Center of Neurology, Moscow, 125367, Russia; Faculty of Ecology, Peoples' Friendship University of Russia, Moscow, 117198, Russia. Electronic address: posibilidad@mail.ru.
2
Laboratory of Clinical and Experimental Neurochemistry, Research Center of Neurology, Moscow, 125367, Russia; Faculty of Biology, Moscow State University, Moscow, 119234, Russia.
3
Laboratory of Clinical and Experimental Neurochemistry, Research Center of Neurology, Moscow, 125367, Russia.
4
Faculty of Ecology, Peoples' Friendship University of Russia, Moscow, 117198, Russia.

Abstract

In a model of early-stage Parkinson's disease induced by a single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to Wistar rats, a neuroprotective effect of a new derivative of carnosine and α-lipoic acid (C/LA nanomicellar complex) was demonstrated. Acute intraperitoneal administration of carnosine, α-lipoic acid and C/LA complex following MPTP administration normalized the total antioxidant activity in the brain tissue. Of all the compounds tested only C/LA complex normalized the metabolism of dopamine (DA) and serotonin (5-HT), while its components did not show similar effects when used separately. C/LA complex effectively restored the level of DA metabolites: the level of DOPAC was increased by 24.7 ± 5.6% compared to the animals that had received MPTP only, and the level of HVA was restored to the values observed in the intact animals. Integral metabolic indices of DA (DOPAC/DA and HVA/DA ratios) and 5-HT turnover (5-HIAA/5-HT ratio) in the striatum tended to increase in case of C/LA complex administration.

KEYWORDS:

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Carnosine; Catecholamines; Lipid peroxidation; Nanomicellar complex of carnosine and α-lipoic acid; Neuroprotection; Parkinson's disease; Rat; α-lipoic acid

PMID:
29601911
DOI:
10.1016/j.yrtph.2018.03.025
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center