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PLoS One. 2018 Mar 30;13(3):e0195411. doi: 10.1371/journal.pone.0195411. eCollection 2018.

Chronic noise-exposure exacerbates insulin resistance and promotes the manifestations of the type 2 diabetes in a high-fat diet mouse model.

Author information

1
Medical College, Southeast University, Nanjing, China.
2
Institute of Life Sciences, Southeast University, Nanjing, China.
3
School of Human Communication Disorder, Dalhousie University, Halifax, Nova Scotia, Canada.

Abstract

Epidemiological studies have revealed that noise exposure was associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the exact nature of that association remains to be elucidated. The present study is designed to examine the effects of chronic noise exposure on the development of T2DM in combination with a high-fat-diet (HFD) in mice. Here we show that chronic noise exposure at 85 dB SPL (4 h /day, below the safety limit for occupational noise exposure) exaggerated multiple metabolic abnormalities induced by HFD in C57BL/6J male mice, including worsened glucose intolerance, insulin resistance, fasting hyperglycemia and dyslipidemia. Furthermore, noise exposure exhibited a paradoxical impact on fat accumulation and circulating levels of free fatty acid, indicating a potential stimulating effect of noise on lipolysis. These results provide first in vivo supporting evidence for the causative role of noise exposure in diabetogenesis and pinpoint a noise-associated increase in blood free fatty acid levels as a possible mediator accelerating the effect of noise on the development of insulin resistance and T2DM.

PMID:
29601606
PMCID:
PMC5877872
DOI:
10.1371/journal.pone.0195411
[Indexed for MEDLINE]
Free PMC Article

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