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Anticancer Res. 2018 Apr;38(4):2207-2215.

Radiotherapy-induced Early ECG Changes and Their Comparison with Echocardiography in Patients with Early-stage Breast Cancer.

Author information

1
Heart and Lung Center, Helsinki University Hospital and Helsinki University, Helsinki, Finland suvi.tuohinen@fimnet.fi.
2
Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
3
Heart Center, Tampere University Hospital, Tampere, Finland.
4
Department of Oncology, Tampere University Hospital, Tampere, Finland.
5
Faculty of Social Sciences, University of Tampere, Tampere, Finland.
6
Heart and Lung Center, Helsinki University Hospital and Helsinki University, Helsinki, Finland.

Abstract

BACKGROUND:

Early electrocardiogram (ECG) changes after breast cancer radiotherapy (RT) have been reported, but their characteristics and associated factors are largely unknown. This study aimed to explore early RT-induced ECG changes and to compare them with echocardiography changes.

MATERIALS AND METHODS:

Sixty eligible patients with chemotherapy-naïve left-sided and 20 with right-sided breast cancer were evaluated with echocardiography, blood samples and ECG before and after RT.

RESULTS:

RT-induced ECG changes in the anterior leads. T-Wave changes were most frequent. T-Wave decline was associated independently with patient age (β=-0.245, p=0.005), mean heart radiation dose (β=1.252, p=0.001) and global systolic strain rate change (β=7.943, p=0.002). T-Wave inversion was associated independently with mean heart radiation dose (β=0.143, p<0.001), global longitudinal strain change (β=0.053, p=0.017) and posterior calibrated integrated backscatter (β=-0.022, p=0.049).

CONCLUSION:

RT-induced ECG changes were prevalent and associated with functional and structural changes in echocardiography. ECG could be used for post-RT cardiac screening.

KEYWORDS:

Breast cancer; ECG; integrated backscatter; radiotherapy; speckle tracking

PMID:
29599341
DOI:
10.21873/anticanres.12463
[Indexed for MEDLINE]

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