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Redox Biol. 2018 Jun;16:352-358. doi: 10.1016/j.redox.2018.03.013. Epub 2018 Mar 20.

Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect.

Author information

1
Medical Faculty, Trakia University, Stara Zagora, Bulgaria.
2
Medical Faculty, Trakia University, Stara Zagora, Bulgaria; Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia, Bulgaria.
3
University Hospital "Tsaritsa Yoanna-ISUL", Sofia, Bulgaria.
4
Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia, Bulgaria.
5
Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), National Institute for Quantum and Radiological Science and Technology (QST), Chiba, Japan; Quantum-state Controlled MRI, National Institute of Radiological Sciences (NIRS), National Institute for Quantum and Radiological Science and Technology (QST), Chiba, Japan.
6
Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), National Institute for Quantum and Radiological Science and Technology (QST), Chiba, Japan.
7
Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), National Institute for Quantum and Radiological Science and Technology (QST), Chiba, Japan; Quantum-state Controlled MRI, National Institute of Radiological Sciences (NIRS), National Institute for Quantum and Radiological Science and Technology (QST), Chiba, Japan; Medical Faculty, Sofia University "St. Kliment Ohridski", Sofia, Bulgaria. Electronic address: bakalova.rumiana@qst.go.jp.

Abstract

This review is directed to the redox-modulating properties and anticancer effect of vitamin K. The concept is focused on two aspects: (i) redox-cycle of vitamin K and its effect on the calcium homeostasis, "oncogenic" and "onco-suppressive" reactive oxygen species and the specific induction of oxidative stress in cancer; (ii) vitamin K plus C as a powerful redox-system, which forms a bypass between mitochondrial complexes II and III and thus prevents mitochondrial dysfunction, restores oxidative phosphorylation and aerobic glycolysis, modulates the redox-state of endogenous redox-pairs, eliminates the hypoxic environment of cancer cells and induces cell death. The analyzed data suggest that vitamin C&K can sensitize cancer cells to conventional chemotherapy, which allows achievement of a lower effective dose of the drug and minimizing the harmful side-effects. The review is intended for a wide audience of readers - from students to specialists in the field.

PMID:
29597144
PMCID:
PMC5953218
DOI:
10.1016/j.redox.2018.03.013
[Indexed for MEDLINE]
Free PMC Article

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